DEPARTMENT OF Musculoskeletal Tumor Center

• Department:Musculoskeletal Tumor Center
• Gender:Male
• Title:Chairman, Department of Orthopedic Oncology; Director,Bone Tumor Research Laboratory, Peking University People\s Hospital

Professional Highlights

Memberships:

Chairman, (Since 2005)Chinese Musculoskeletal Tumor Sosiety (CMSTS)

Chairman, (2006-2008) Asia-Pacific Musculoskeletal Tumor Sosiety (APMSTS)

Chairman (2009-2011), International Society on Limb Salvage (ISOLS)

Board Member, International Society on Limb Salvage (ISOLS)

Board Member, Chinese Orthopaedic Association

Board Member, Chinese Society of Clinical Oncology

Board Member, Beijing Orthopaedic Association

Board Member, Asia-Pacific Musculoskeletal Tumor Sosiety (APMSTS)

Member, Asia-Pacific Orthopaedic Association

Board Member, Chinese Sarcoma Group

Award：

1, Science & Technology Achievement Award，The Ministry of Education (1999)—“Cytobiological, cytogenetic and immunological study in giant cell tumor”.

2, Science & Technology Achievement Award, Beijing Municipal Government(2001)—“Molecular biology study in primary malignant bone tumor”.

3, Science & Technology Achievement Award, Beijing Municipal Government(2003)—“Etiological study in primary bone tumor”.

4, Science & Technology Achievement Award, The Chinese Medical Association(2003)—“Etiological mechanism study in primary bone tumor”.

5, Science & Technology Achievement Award, Beijing Municipal Government(2005)—“Clinical and basic reserch in chemotherapy for Osteosarcoma”.

6, Science & Technology Achievement Award, The Chinese Medical Association(2009)—“Resection and functional reconstruction for pelvic ring tumor”.

7, Science & Technology Achievement Award, Beijing Municipal Commission of Science and Technology (2011)——“Resection and functional reconstruction for pelvic ring tumor”.

8, The Twelfth Wu Jieping-Paul Janssen Medical Reseach Award (2012).

9, Science & Technology Achievement Award, The Chinese Medical Association(2013)—“Serial studies in standardized resection and functional reconstruction of primary malignant bone tumor”

10, National Science & Technology Progress Award, Ministry of Science and Technology (2014)—“Serial studies of standardized resection and functional reconstruction of primary malignant bone tumor”.

Interests

Limb salvage in malignant bone and soft tissue tumor
Surgical treatment of pelvic and sacral tumor
Surgical treatment of spinal tumor
Chemotherapy inmalignant bone and soft tissue tumor

Research & Publications

1, Guo Wei et al (1999) Mechanisms of Methotrexate Resistance in Osteosarcoma. Clin Cancer Res 5: 621.
2, Guo Wei et al (1999) Expression of Genes Encocding Bone Morphogenetic Proteins and Their Receptors in Sarcomas.  Clin Orthop 8：175-183.
3, Guo Wei, et al (1999) CDK4 gene amplification in osteosarcoma: reciprocal relationship with INK4A gene alterations and mapping of 12q13 amplicons. Int. J Cancer 80, 199-204.
4, Guo Wei, et al (2000) Secondary Genetic Alterations in Ewing’ sarcoma: Prognostic Impact of INK4A Deletion.  Cancer 89(4):793-799.
5, Guo Wei, et al (1999) COMPARATIVE FREQUENCY OF BONE SARCOMAS AMONG DIFFERENT RACIAL GROUPS. Chinese Medical Journal. (English Ed) 112(12):1101-1104.
6, Guo Wei, et al. Paclitaxel-induced apoptosis in osteosarcoma cell line U-2 OS.  Chinese Medical Journal. (English Ed) 115（12）1796-1801, 2002.
7, Guo Wei, Dasen Li, Xiaodong Tang, et al. Modular Hemipelvic Prosthesis Reconstruction of Acetabulem after Resection of Periacetabular Tumors. Clin Orthop, 461:180-188, 2007.
8, Guo W, Guo Y, Tang S, et al. Dendritic Cell-Ewing’s Sarcoma Cell Hybrids Enhance Antitumor Immunity. Clin Orthop Relat Res.466:2176-2183, 2008
9, Guo W , Ji T, Tang X, et al. Megaprostheses Replacement for Primary Tumors around the Knee-Experience from Peking University. J Bone Joint Surg [Br], 2008, 90-B:1084-1089.
10, Ji T, Guo W, Shen DH, et al. Intradural spinal seeding and fatal progression of a sacrococcygeal chordoma: a case report. Chin Med J 2008, 1210:1-4.
11, Peng C, Guo W, Yang Y, et al. Downregulation of SS18-SSX1 expression by small interfering RNA inhibits growth ang induces apoptosis in human synovial sarcoma cell line HS-SY-a in vitro. Euro J Cancer Preven, 2008, 17：392-398.
12, Hui Zhao, Wei Guo, Changliang Peng, et al. Arsenic trioxide inhibits the growth of Adriamycin resistant osteosarcoma cells through inducing apoptosis. Mol Biol Rep,2010, 37(5):2509-2515.
13, Tang X, Guo W, Yang R, et al. Assessment of Risk Factors for Blood Loss during Sacral Tumor Resection. Clin Orthop Relat Res. 2009, Jun;467(6):1599-604.
14, Guo W. Tang X, Yang Y, et al. Outcome of conservative surgery for giant cell tumor of the sacrum. Spine. 2009, May 1;34(10):1025-31.
15, Tang X, Guo W, Yang R, et al. Evaluation of blood loss during limb salvage surgery for pelvic tumours. Int Orthop. 2009 Jun;33(3):751-6.
16, Guo Wei, Tang Xiaodong , Yang Yi, et al.  Strategy of Surgical Treatment of Sacral Neurogenic Tumors. Spine, 2009, 34(23):2587-2592.
17, Tang X, Guo W, Yang R, et al. Custom-made prosthesis replacement for reconstruction of elbow after tumor resection. J Shoulder Elbow Surg (2009) 18,796-803.
18, Chang-liang Peng, Wei Guo, Tao Ji, et al. Sorafenib induces growth inhibition and apoptosis in human synovial sarcoma cells via inhibiting the RAF/MEK/ERK signaling pathway. Cancer Biology & Therapy. 8:18, 1729-1736. 2009.
19, Tang X, Guo W, Yang R, et al.  Aortic balloon occlusion decrease blood loss during sacral tumor resection.  J Bone Joint Surg Am, 2010, 92(8):1747-53.
20, Wei Guo, Dasen Li, Xiaodong Tang, et al. Surgical Treatment of Pelvic Chondrosarcoma Involving Periacetabulum. J Surg Oncol, 2010, 101(2):160-165.
21, Du Zhi-Ye, Zang Jie, Guo Wei, et al. Expert’s agreement on therapy for bone metastases. Orthopaedic Surgery; 2010; 2(4)：241-253.
22, Tang G, Yan T, Guo W, et al. "(-)-Epigallocatechin-3-gallate induces apoptosis and suppresses proliferation by inhibiting the human Indian Hedgehog pathway in human chondrosarcoma cells. J Cancer Res Clin Oncol. 2010，136：1179-1185.
23, Lu X, Tang X, Guo W, et al. Sorafenib induces growth inhibition and apoptosis of human chondrosarcoma cells by blocking RAF/ERK/MEK pathway. J Surg Oncol, 2010, 102(7):821-826.
24, Tang X, Lu X, Guo W, Ren T, et al. Different expression of Sox9 and Runx2 between chondrosarcoma and dedifferentiated chondrosarcoma cell lines. Eur J Cancer Prev. 2010 ;19(6):466-471.
25, Ren Ting-ting, Guo Wei, et al. Arsenic trioxide inhibits osteosarcoma cell innasiveness via MAPK signaling pathway. Cancer Biol Ther. 2010;10(3);251-257.
26, Ji Tao, Guo Wei, et al. Reconstruction of type II+III pelvic resection with a modular hemipelvic endoprosthesis : a finite elememt analysis study.  Orthopaedic Surgery; 2010;2(4):272-277.
27, T. Ji, W. Guo, R.-L. Yang, et al. Clinical outcome and quality of life after surgery for peri-acetabular metastases. J Bone Joint Surg[Br],2011;93-B：1104-10.
28, T Yan, G Tang, T Ren，et al. RNAi-mediated COPS3 gene silencing inhibits metastasis of osteogenic sarcoma cells. Cancer Gene Therapy (2011) 18, 450–456.
29, D. Li, W. Guo, X. Tang, et al. Surgical classification of different types of en bloc resection for primary malignant sacral tumors. Eur Spine J（2011）20：2275-2281.
30, X．Tang，W. Guo, R. Yang, et al. Reconstruction with constrained prosthesis after total scapulectomy. J Shoulder Elbow Surg (2011)20, 1163-1169.
31, Tang X, Guo W, Ji T. Reconstruction with modular hemipelvic prosthesis for the resection of solitary periacetabular metastasis. Arch Orthop Trauma Surg （2011）131：1609-1615。
32, F.Zhao, W.Guo, et al. Expression of stromal derived factor-1(SDF-1)and chemokine receptor(CXCR4)in bone metastasis of renal carcinoma. Mol Biol Rep, 2011, 38(2):1039-1045.
33, W. Guo, X. Sun, J. Zang & H. Qu. Intralesional Excision versus Wide Resection for Giant Cell Tumor Involving the Acetabulum: Which is Better?
Clin Orthop Relat Res. 2012, 470 :1213-1220.
34, S．Zhang, W. Guo, T.T.Ren, et al. Arsenic trioxide inhibits Ewing’s sarcoma cell invasiveness by targeting p38MAPK and c-Jun N-terminal kinase. Anti Cancer Drugs. 2012, 23(1)108-118.
35, Guo W, Sun X, Ji T, Tang X. Outcome of surgical treatment of pelvic osteosarcoma. J Surg Oncol. 2012；106:406-410
36, Xie L, Guo W, Li Y, et al. Pathologic Frecture Dose Not Influence Local Recurrence and Survival in High-Grade Extremity Osteosarcoma With Adequate Surgical Margians. J Surg Oncol. 2012;106:820-825.
37, T.Ji, W.Guo, R.L.Yang, et al. Modular hemipelvic endoprosthesis reconstruction-Experience in 100 patients with mid-term follow-up results. Eur J Surg Oncol, 2013，39（1）53-60.
38, Wei Guo, Xiaodong Tang, Jie Zang,et al. One-Stage Total en bloc Sacrectomy- A Novel Technique and Report of 9 Cases. Spine, 2013，38（10）626-631.
39, Zhiyuan Lou, Yi Yang, Tingting Ren, et al. Smad3 is the key to transforming growth factor-b1-induced osteoclast differentiation in giant cell tumor of bone. Med Oncol (2013) 30:606
40, Li D, Guo W, Qu H,et al. Experience with wound complications after surgery for sacral tumors. Eur Spine J. 2013 Sep;22(9):2069-76.
41, G．Jiao, T. Ren, Q. Lu, et al. Prognostic significance of cyclooxygenase-2 in osteosarcoma:a meta-analysis. Tumor Biol. 2014, DOI 10.1007/s13277-013-0998-2
42, T. Ren, Q. Lu, W. Guo, et al. The clinical implication of SS18-SSX fusion gene in synovial sarcoma. British J Cancer, 2013, 1–7 | doi: 10.1038/bjc.2013.547.
43, Z. Lou, T. Ren, X. Peng, et al. Bortezomib induces apoptosis and autophagy in osteosarcoma cells through mitogen-activated protein kinase pathway in vitro. J Int Med Res, 2013, 41(5)1505-1519.
44, Tao Ji, Xiaodong Tang, Wei Guo. The Use of Ligament Advanced Reinforcement System(LARS) in Limb Salvage Surgery. A Pilot Clinical Study. J Arthroplasty, 28(2013)892-894.
45, Xianbo Peng, Wei Guo, et al. Differential Expression of the RANKL/RANK/OPG System Is Associated with Bone Metastasis in Human Non-Small Cell Lung Cancer. PLoS ONE(2013) 8(3): e58361.
46, Ji T, Guo W, Tang X. Enhancement of Soft Tissue Reattachment in Proximal Huemral Endoprosthetic Recosntruction. J Orthop Surg (Hong Kong)，2014,22（1）：100-3.
47, Dasen Li, Wei Guo, Xiaodong Tang, et al. Preservation of the contralateral sacral nerves during hemisacrectomy for sacral malignancies. Eur Spine J. （2014）29:1933-1939.
48, Tai-Qiang Yan, Wen-Hao Zhou, Wei Guo, et al. Endoprosthetic recongstruction for large extremity soft-tissue sarcoma with juxta-articular bone involvement: functional and survival outcome. J Surg Res,187(2014)142-149.
49, L. Xie, X.D. Tang, R.L. Yang and W. Guo. Interscapulothoracic resection of tumors of shoulder with a note on reconstruction. Bone Joint J, 2014;96:B:684-90.
50, Tao Ji, Ramez Eskander, Yifei Wang,et al. Can surgical manement of bone metastases improve quality of life among women with gynecologic cancer? World J Surg Oncol, 2014, 12:250.
51, Tang X, Guo W, Yang R Wang Y. Poor prognosis and complication are common in limb salvage surgery for malignant tumors of the proximal tibia invading the fibular. Arch Orthop Trauma Surg, 2014, 134(3)；299-304.
52, Zang J, Guo W, Yang Y, Xie L. Reconstruction of the hemipelvis with a modular prosthesis after resection of a primary malignant peri-acetabular tumor involving the sacroiliac joint. Bone Joint J, 2014;96-B(3):399-405.
53, Y Sun, W Guo, T Ren, et al. Gli1 inhibition suppressed cell growth and cell cycle progression and induced apoptosis as well as autophagy depending on ERK1/2 activity in human chondrosarcoma cells. Cell death & disease (2014) 5, e979; doi:10.1038/cddis.2013.497.
54, G Jiao, W Guo, T Ren, et al. BMPR2 inhibition induced apoptosis and autophagy via destabilization of XIAP in human chondrosarcoma cells. Cell Death and Disease (2014) 5, e1571; doi:10.1038/cddis.2014.540
55, Xiaodong Tang MD, Wei Guo MD,PhD, Rongli Yang,MD, et al. Synthetic Mesh Improves Shoulder Function After Intraarticular Resection and Prosthetic Replacement of Proximal Humerus. Clin Orthop Relat Res, 2015.
56, H. Qu, W. Guo, R. Yang, et al. Cortical strut bone grafting and long-stem endoprosthetic reconstruction following massive bone tumour resection in the lower limb. Bone Joint J, 2015:97-B:544-9.
57, Jie Zang, Wei Guo, et al. Is total en bloc sacrectomy using a posterior-only approach feasible and safe for patients with malignant sacral tumors? J Neurosurg Spine, 2015; 22(6): 563-70.
58, Huayi Qu,Wei Guo,Rongli Yang,Dasen Li,et al. Reconstruction of segmental bone defect of long bones after tumor resection by devitalized tumor-bearing bone. Word journal of Surgical Oncology(2015)13:282.
59, Yi-fei Wang, Wei Guo, Kun-kun Sun, Rong-li Yang, Xiao-dong Tang, Tao Ji, Shun Tang.Postoperative recurrence of desmoid tumors: clinical and pathological perspectives.World J Surg Oncol. (2015)13: 26.
60, XuJ, LiD,XieL,TanS,GuoW. esenchymal chondrosarcoma of bone and soft tissue: a systematic review of 107 patients in the past 20 years. PLOS ONE.2015 Apr 7;10(4)
61, Tao Ji, Yi Guo, et al.Neuropilin-2 expression is inhibited by secreted Wnt antagonists and its down-regulation is associated with reduced tumor growth and metastasis in osteosarcoma. Molecular Cancer (2015)14:86.
62, Tang B, Ji T, Tang X, Jin L, Dong S, Guo W.  Risk factors for major complications in surgery for hypervascular spinal tumors: an analysis of 120 cases with adjuvant preoperative embolization. Eur Spine J. 2015;24(10):2201-8.
63, Huang L, Guo W, Yang R, Tang X, Ji T. A Proposed Scoring System for Evaluating Neurologic Deficit after Sacral Resection: Functional Outcome of 170 Consecutive Patietns. Spine. 2016;41(7):628-37
64, Kang Yang, Xiaodong Tang, Wei Guo, et al. BMPR2-pSMAD1/5 signaling pathway regulates RUNX2 expression and impacts the progression of dedifferentiated chondrosarcoma. Am J Cancer Res 2016;6(6):1302-1316.
65, Xiaolong Xu, Xiaodong Tang, Wei Guo, et al. TCF-1 participates in the occurrence of dedifferentiated chondrosarcoma. Tumor Biol. 2016, DOI10.1007/s13277-0165235-3.
66, Xu X,Tang X,Guo W,et al.TCF-1 participates in the occurrence of dedifferentiated chondrosarcoma.Tumour Biol.2016,37(10):14129-14140
67, Lu xie, Wei Guo,Xiaodong Tang,Yi Yang,Jie Xu. Effects of Arsenic Trioxide on Minor Progressive High-Grade Osteosarcoma of the Extremities Metastatic to the Lung- Results of 39 Patients Treated in a Single Institution. Case Reports in Oncology. DOI:10.1159/000448705
68, Ren C, Ren T, Yang K, Wang S, Bao X, Zhang F, Guo W. Inhibition of SOX2 induces cell apoptosis and G1/S arrest in Ewings sarcoma through the PI3K/Aktpathway. J Exp Clin Cancer Res. 2016 Mar 11;35:44. doi: 10.1186/s13046-016-0321-3.
69, Bao X, Ren T, Huang Y, Wang S，et al . Induction of the mesenchymal to epithelial transition by demethylation-activated microRNA-125b is involved in the anti-migration/invasion effects of arsenic trioxide on human chondrosarcoma. J Exp Clin Cancer Res. 2016 Aug 30;35(1):129. doi: 10.1186/s13046-016-0407-y.
70, Tao Ji, Wei Guo, Rongli Yang，et al. What Are the Conditional Survival and Functional Outcomes After Surgical Treatment of 115 Patients With Sacral Chordoma? Clin Orthop Relat Res, 2016,
71, Haijie Liang, Dasen Li, Wei Guo, Rongli Yang, Xiaodong Tang. Lateral lumbar limbvertebral body screw predisposes to neuralgia after limb-salvage surgery for pelvic tumors: a single-center, retrospective study of 349 cases. European Spine Journal (2016) 25(12), 4094-4102
72, Zhang YD, Guo W,Yang RL, Tang XD,Yan TQ,Ji T, Malignant Pelvic Tumors Involving the Sacrum: Surgical Approaches Based on a New Classification. Orthop Surg. 2016 May:8(2):150-61.doi:10.1111/os.12240
73，Haijie Liang, Tao Ji, Yidan Zhang, Yifei Wang, Wei Guo. Reconstruction with 3D-printed pelvic endoprostheses after resection of a pelvic tumor. Bone Joint Journal. 2017 Feb;99-B(2):267-75.
74, One step reconstruction with a 3D printed, custom-made prosthesis after total en bloc sacrectomy: a technical note. Eur spine J, 2017.