DEPARTMENT OF Obstetrics & Gynecology

• Department:Obstetrics & Gynecology
• Gender:Female
• Title:Professor of Obstetrics and Gynecology

Professional Highlights

Member of a council, China Medicinal Biotech Association, 2013-2017
Member of the Commission, Obstetrics and Gynecology, China Medical Womens Association,2012-2017
Editorial board,Chinese Journal of Obstetrics and Gynecology, 2015-2020
Editorial board,Chinese Medicine Biotechnology journal, 2012-2017

Interests

Endometriosis, Ovarian Carcinoma, Immunotherapy of Tumor
Biomarker, Antigen and Antibody, anti-idiotypic antibody, Proteomics and Pathogenesis in Gynecologic Oncology and Endometriosis

Research & Publications

1. Zhang C1, Gao L1, Yi Y1, Han H2, Cheng H1, Ye X1, Ma R1, Sun K3, Cui H1, Chang X4.Adenosine Triphosphate Regresses Endometrial Explants in a Rat Model of Endometriosis. Reprod Sci. 2016 Jul;23(7):924-30.
2. Jiang J1, Bo D1, Chang X1, Cheng H1, Ye X1, Cui H1. Discrepant clinicopathologic characteristics and HE4 performance in type I and type II epithelial ovarian cancer. Int J Clin Exp Med. 2015 Nov 15;8(11):21303-10.
3. Ji F1, Chang X2, Liu C2, Meng L1, Qu L1, Wu J1, Liu C2, Cui H2, Shou C1.Prognostic value and characterization of the ovarian cancer-specific antigen CA166-9. Int J Oncol. 2015 Oct;47(4):1405-15.
4. He XJ1, Zhang Q1, Ma LP1, Li N1, Chang XH2, Zhang YJ1.Aberrant Alternative Polyadenylation is Responsible for Survivin Up-regulation in Ovarian Cancer. Chin Med J (Engl). 2016 20th May;129(10):1140-1146.
5. Zhao Y, Liu YN, Li Y, Tian L, Ye X, Cui H, Chang XH1.Identification of biomarkers for endometriosis using clinical proteomics. Chin Med J (Engl). 2015;128(4):520-7.
6. Li Gao1, Xue Ye1, Rui‑Qiong Ma1, Hong‑Yan Cheng1, Hong‑Jing Han2, Heng Cui1, Li‑Hui Wei1, Xiao‑Hong Chang1. Low Programmed Cell Death 5 Expression is a Prognostic Factor in Ovarian Cancer.Chin Med J (Engl). 2015;128(8):1084-1090
7. Ma R1, Ye X1, Cheng H1, Ma Y1, Cui H2, Chang X3. PRSS3 expression is associated with tumor progression and poor prognosis in epithelial ovarian cancer.Gynecol Oncol. 2015 Jun;137(3):546-52.
8. Cheng H1, Ye X, Chang X, Ma R, Cong X, Niu Y, Zhang M, Liu K, Cui H, Sang J.Construction, expression, and function of 6B11ScFv-mIL-12, a fusion protein that attacks human ovarian carcinoma. Med Oncol. 2015 Apr;32(4):130.
9. Tang Z1, Chang X1, Ye X1, Li Y1, Cheng H1, Cui H1.Usefulness of human epididymis protein 4 in predicting cytoreductive surgical outcomes for advanced ovarian tubal and peritoneal carcinoma. Chin J Cancer Res. 2015 Jun;27(3):309-17.
10. Kong X1, Chang X, Cheng H, Ma R, Ye X, Cui H. Human Epididymis Protein 4 Inhibits Proliferation of Human Ovarian Cancer Cells Via the Mitogen-Activated Protein Kinase and Phosphoinositide 3-Kinase/AKT Pathways. Int J Gynecol Cancer. 2014 Mar;24(3):427-36.
11. Chen X1, Zhang Z1, Chang X1, Niu Y2, Cui H1. Production of transgenic mice expressing tumor virus A under ovarian‑specific promoter 1 control using testis‑mediated gene transfer.Mol Med Rep. 2014 Mar;9(3):955-60.
12. Zhang, Z.; Chen, X.; Chang, X.; Ye, X.; Li, Y.; Cui, H*. Vaccination with embryonic stem cells generates effective antitumor immunity against ovarian cancer, Int J Mol Med, 31, (1), 147-53. 2013
13. Zhang, Z. J.; Chen, X. H.; Chang, X. H.; Ye, X.; Li, Y.; Cui, H*. Human embryonic stem cells--a potential vaccine for ovarian cancer, Asian Pac J Cancer Prev, 13, (9), 4295-300. 2012
14. Chanzhen Liu, Li Zhang, Xiaohong Chang, Yexia Cheng, Hongyan Cheng,XueYe, Tianyun Fu, Jun Chen, Heng Cui*. Overexpression and Immunosuppressive Functions of Transforming Growth Factor 1, Vascular Endothelial Growth Factor, and Interleukin-10 in Epithelial Ovarian Cancer. Chinese Journal of Cancer Research.2012；24(2):130-137
15. Chang X, Ye X,Dong L,Cheng H,Cheng Y,Zhu L,Liao Q, Zhao Y, Tian L, Fu T, Chen J, Cui H. Human Epididymis Protein 4 (HE4) as a Serum Tumor Biomarker in Patients With Ovarian Carcinoma.Int J Gynecol Cancer. 2011 Jul;21(5):852-8.
16. Zou SL, Chang XH, Ye X, Cheng HY, Cheng YX, Tang ZJ, Zhang ZJ, Gao L, Chen XH, Cui H. Effect of human epididymis protein 4 gene silencing on the malignant phenotype in ovarian cancer.Chin Med J (Engl). 2011 Oct;124(19):3133-40.
17. L GAO, HY CHENG, L DONG, X YE, YN LIU, XH CHANG, YX CHENG, J CHEN, RQ MA AND H CUI. The Role of HE4 in Ovarian Cancer: Inhibiting Tumour Cell Proliferation and Metastasis  .The Journal of International Medical Research, 2011;39(5):1645-1660.
18. ZHANG Hong, FENG Jie, CHANG Xiao-hong, LI Zhong-xing, WU Xiao-yi , CUI Heng. Effect of surface-enhanced laser desorption/ionization time-of-flight mass spectrometry on identifing biomarkers of endometriosis. Chinese Medical Journal, 2009, Vol. 122 No. 4: 373-376
19. Xiaohong Chang, Li Zhang, Rong Yang, Jie Feng, Yexia Cheng, Hongyan Cheng, Xue Ye,Tianyun Fu Heng Cui. Screening for genes associated with ovarian cancer prognosis. Chinese Medical Journal 2009;122(10):1167-1172
20. Wenlan Yang , Jie Feng, Xiaohong Chang, Tianyun Fu , Xue Ye, Hong Zhang, Xiaoping  Li ,Hongwu Wen , Limin Feng , Chunrong Tongd, Heng Cui. Cytotoxic effects of T cells induced by fusion protein 6B11-pulsed dendritic cells on ovarian carcinoma cells. Gynecologic Oncology. 105 (2007) 238-243
21. Wei Li , Heng Cui , Fan-Qiang Meng, Xiao-Hong Chang, Guo Zhang , Bei Liu, Zi-Hai Li.New T cell epitopes identified from an anti-idiotypic antibody mimicking ovarian cancer associated antigen. Cancer Immunol Immunother. 2008,57:143-154
22. Jingjing Shi, Xiaohong Chang, Jie Feng, Yexia Cheng, Hongyan Cheng, Huifang Guo, Xue Ye and Heng Cui. Expression of an Ovarian Cancer Anti-idiotype Antibody (6B11VLVHCH3) in CHO Cells with Improved Immunoactivity and Stability Over Proteins Expressed in Prokaryotic Cells. HYBRIDOMA. Volume 26, Number 5, 2007:289-295.
23. CHANG Xiao-Hong， CUI Heng， FENG Jie， LI Yi et al.  Humoral immune responses induced by anti-idiotypic antibody fusion protein of 6B11scFv/hGM-CSF in BALB/c mice. Chinese Medical Journal. 2006: 119(2):131-139.
24. Chang xiaohong, Cui heng, Feng jie, Li yi, liu bei, Cao shanjin Cheng yexia and Qian Henian. Preparation of humanized ovarian carcinoma anti-idiotypic minibody. Hybridoma 2003, 22:109-115
25. Cui H, Chang XH, Liu B et.al. The anti-tumor immune responses induced by a fusion protein of ovarian carcinoma anti-idiotypic antibody 6B11ScFv and Murine GM-CSF in BALB/c mice. Int J Gynecologic Cancer.2004; 14:1-8.