DEPARTMENT OF Rheumatology & Immunology

• Department:Rheumatology & Immunology
• Gender:Male
• Title:Professor, Chief of Department of Rheumatology and Immunology

Professional Highlights

Founder of International Forum of Rheumatoid arthritis which takes place annually since 2009

Interests

Mechanism and early diagnose and immunotherapy of SLE and RA

Research & Publications

1. Jing He, Xia Zhang, Yunbo Wei, Xiaolin Sun, Yaping Chen, Yuebo Jin, Xin Hu, RulinJia, ChuanhuiXu, ZhaohuaHou, Lei Zhu, JinhongFeng, Yuan An, Yuan Jia, Chun Li, Xu Liu, Hua Ye, LiminRen,Ru Li, Haihong Yao, Yuhui Li, Shi Chen,Xuewu Zhang, Yin Su, JianpingGuo, Nan Shen, Eric F. Morand, Di Yu and Zhanguo Li. Low-dose interleukin-2 treatment modulates CD4+ T cell subsets selectively in patients with systemic lupus erythematosus. Nature Medicine. 2016;22(9):991-3
2. Liu Y, Mu R, Gao YP, Dong J, Zhu L, Ma Y, Li YH, Zhang HQ, Han D, Zhang Y, McInnes IB, Zhang J, Shen B, Yang G, Li ZG.A Cytomegalovirus Peptide-Specific Antibody Alters Natural Killer Cell Homeostasis and Is Shared in Several Autoimmune Diseases. Cell Host Microbe. 2016;19(3):400-8.
3. Zhan-guo Li. A new look at rheumatology in China——opportunities and challenges. Nat Rev Rheum, 2015;11 (5):313-317
4. He J, Tsai LM, Leong YA, Hu X, Ma CS, Chevalier N, Sun X, Vandenberg K, Rockman S, Ding Y, Zhu L, Wei W, Wang C, Karnowski A, Belz GT, Ghali JR, Cook MC, Riminton DS, Veillette A, Schwartzberg PL, Mackay F, Brink R, Tangye SG, Vinuesa CG, Mackay CR, Li Z﹡, Yu D﹡. Circulating precursor CCR7(lo)PD-1(hi) CXCR5+ CD4+ T cells indicate Tfh cell activity and promote antibody responses upon antigen reexposure. Immunity, 2013; 39(4):770-81.
5. Liling Xu, Mengdie Xia, Jun Guo, Xiaolin Sun, Hua Li, Chenguang Xu, Xiaomei Gu, Haowen Zhang, Junyang Yi, Yan Fang, Hengyi Xie, Jing Wang, Zhixun Shen, Boxin Xue, Yujie Sun, Tobias Meckel, Ying‑Hua Chen, Zhibin Hu, Zhanguo Li, Chenqi Xu, Haipeng Gong, and Wanli Liu. Impairment on the lateral mobility induced by structural changes underlies the functional deficiency of the lupusassociated polymorphism FcγRIIB-T232s. J Exp Med. Published on-line October 31, 2016
6. HU F，Mu R，Zhu J，Shao WW，Shi LJ，Philip L. Cohen，Qiu XY，Li ZG. Hypoxia and hypoxia-inducible factor-1α provoke toll-like receptor signalling-induced inflammation in rheumatoid arthritis. Ann Rheum Dis 2014;73:928-936.
7. Wang, T., X. Sun, J. Zhao, J. Zhang, H. Zhu, C. Li, N. Gao, Y. Jia, D. Xu, F. P. Huang, N. Li, L. Lu, and Z. G. Li. Regulatory T cells in rheumatoid arthritis showed increased plasticity toward Th17 but retained suppressive function in peripheral blood. Ann Rheum Dis. 2015;74 (6):1293-1301
8. Du, Y., Y. Cui, X. Liu, F. Hu, Y. Yang, X. Wu, X. Ma, X. Zuo, Y. Sheng, J. Xu, P. Zhu, L. Sun, N. Hong, X. Zhang, J. Guo, and Z. Li. Contribution of functional LILRA3, but not nonfunctional LILRA3, to sex bias in susceptibility and severity of anti-citrullinated protein antibody-positive rheumatoid arthritis. Arthritis Rheumatol.2014; 66:822-830.
9. Joel Kremer, Zhan-Guo Li, Stephen Hall, Roy Fleischmann, Mark Genovese, Emilio Martin-Mola, John D. Isaacs, David Gruben, Gene Wallenstein, Sriram Krishnaswami, Samuel H. Zwillich, Tamas Koncz, Richard Riese, John Bradley. Tofacitinib in Combination With Nonbiologic Disease-Modifying Antirheumatic Drugs in Patients With Active Rheumatoid Arthritis. Ann Intern Med. 2013;159:253-261
10. Zhao J, Ma J, Deng Y, Kelly JA, Kim K, Bang SY, Lee HS, Li QZ, Wakeland EK, Qiu R, Liu M, Guo J, Li Z, Tan W, Rasmussen A, Lessard CJ, Sivils KL, Hahn BH, Grossman JM, Kamen DL, Gilkeson GS, Bae SC, Gaffney PM, Shen N, Tsao BP. Nat Genet. 2017 Jan 30. doi: 10.1038/ng.3782.