Endocrinology and Metabolism & Hypertension | A Landmark Diabetes Prevention Study Led by Prof. Ji Linong and Prof. Sun Ningling of Peking University People’s Hospital Published in Lancet Subsidiary Journal
内分泌科纪立农、高血压科孙宁玲团队关于糖尿病预防研究成果在《柳叶刀》子刊发表

2023-09-23

In a groundbreaking development, a research paper led by prominent figures in the medical field has been published, revealing significant advancements in the prevention of diabetes in the Chinese population. The paper, titled "Safety and effectiveness of metformin plus lifestyle intervention compared with lifestyle intervention alone in preventing progression to diabetes in a Chinese population with impaired glucose regulation: a multicentre, open-label, randomised controlled trial," was published on July 4, 2023 (July 3 in London time) in the prestigious journal The Lancet Diabetes & Endocrinology (IF=44.867).

The study delivers groundbreaking insights. According to the findings, the combination of metformin and lifestyle intervention proves to be more effective than lifestyle intervention alone in slowing down the progression from prediabetes to diabetes among the Chinese adult population. This not only ensures improved safety but also brings forth multiple health benefits.

The implications of this research are monumental, offering a novel solution for the primary prevention of diabetes in China. This breakthrough contributes crucial scientific evidence supporting the use of metformin in diabetes prevention. Clinicians now have a reinforced empirical basis for utilizing metformin in primary diabetes prevention, and the study serves as a valuable reference for international research on related topics.

The first author of this paper is Professor Zhang Lihui from the Second Hospital of Hebei Medical University. Co-corresponding authors include Professor Li Guangwei from Fuwai Hospital of the Chinese Academy of Medical Sciences  (CAMS), Professor Ji Linong and Professor Sun Ningling from Peking University People’s Hospital. This collaborative effort marks a significant stride toward a healthier future for the Chinese population and beyond. Stay tuned for further developments on this groundbreaking discovery.

Paper Link: https://www.thelancet.com/journals/landia/article/PIIS2213-8587(23)00132-8/fulltext